串扰
糖尿病肾病
发病机制
肾
肾病
旁分泌信号
糖尿病
内分泌系统
生物
生物信息学
医学
平衡
内分泌学
内科学
免疫学
激素
受体
物理
光学
作者
Ming Yang,Shilu Luo,Jinfei Yang,Wei Chen,Liyu He,Di Liu,Li Zhao,Xi Wang
标识
DOI:10.1016/j.ejphar.2022.175219
摘要
Diabetic nephropathy (DN) is a serious complication of diabetes, and its pathogenesis has not been fully elucidated. Recently, communication between organs has gradually become a new focus in the study of diseases pathogenesis, and abnormal interorgan communication has been proven to be involved in the occurrence and progression of many diseases. As an important metabolic organ in the human body, the liver plays an important role in maintaining homeostasis in humans. The liver secretes a series of proteins called hepatokines that affect adjacent and distal organs through paracrine or endocrine signaling pathways. In this review, we summarize some of the hepatokines identified to date and describe their roles in DN to discuss the possibility that the liver-renal axis is potentially useful as a therapeutic target for DN. We summarize the important hepatokines identified thus far and discuss their relationship with DN. We propose for the first time that the “liver-renal axis” is a potential therapeutic target in individuals with DN.
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