威尼斯人
髓系白血病
阿扎胞苷
医学
髓样
白血病
癌症研究
肿瘤科
内科学
免疫学
生物
遗传学
慢性淋巴细胞白血病
基因
DNA甲基化
基因表达
作者
Fiona C. Brown,Xin Wang,Richard W. Birkinshaw,Chong Chyn Chua,Thomas Morley,Sila Kasapgil,Giovanna Pomilio,Piers Blombery,David C.S. Huang,Peter E. Czabotar,Salvatore F. Priore,Guang Yang,Martin Carroll,Andrew H. Wei,Alexander E. Perl
标识
DOI:10.1182/bloodadvances.2024014446
摘要
We report and characterize three venetoclax-resistant BCL2 variants arising during venetoclax/azacitidine therapy in acute myeloid leukemia (AML). Our results indicate the potential for on-target venetoclax resistance in patients with AML at relapse.
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