三氟甲基化
级联
化学
组合化学
基质(水族馆)
电化学
肟
阳极
有机化学
三氟甲基
电极
地质学
海洋学
物理化学
色谱法
烷基
作者
Kingshuk Mahanty,Suman Kumar Saha,Atreyee Halder,Suman De Sarkar
摘要
The developed methodology describes an environmentally benign protocol for electro-oxidative CF3-radical generation, followed by cascade cyclization fabricating an isoxazoline scaffold from a β,γ-unsaturated oxime. Consecutive C-O and C-C bond formations were achieved through this method featuring mild, robust, and scalable reaction conditions and broad substrate scope. Mechanistic studies revealed the necessity of anodic oxidation for the cascade process. Further conversion of the isoxazoline afforded other valuable derivatives.
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