脂肪组织
炎症
内质网
未折叠蛋白反应
脂毒性
医学
内分泌学
脂质代谢
胰岛素抵抗
内科学
高脂血症
代谢综合征
2型糖尿病
糖尿病
生物
细胞生物学
作者
Kaile Ma,Yanjiao Zhang,Jianmin Zhao,Lijuan Zhou,Min Lü
标识
DOI:10.3389/fimmu.2024.1381227
摘要
Obesity presents a significant global health challenge, increasing the susceptibility to chronic conditions such as diabetes, cardiovascular disease, and hypertension. Within the context of obesity, lipid metabolism, adipose tissue formation, and inflammation are intricately linked to endoplasmic reticulum stress (ERS). ERS modulates metabolism, insulin signaling, inflammation, as well as cell proliferation and death through the unfolded protein response (UPR) pathway. Serving as a crucial nexus, ERS bridges the functionality of adipose tissue and the inflammatory response. In this review, we comprehensively elucidate the mechanisms by which ERS impacts adipose tissue function and inflammation in obesity, aiming to offer insights into targeting ERS for ameliorating metabolic dysregulation in obesity-associated chronic diseases such as hyperlipidemia, hypertension, fatty liver, and type 2 diabetes.
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