Relationship Between CRP/ALB Ratio and Severity of Coronary Artery Lesions in Hypertensive Patients with Acute Myocardial Infarction

BACKGROUND Hypertension is a significant risk factor for acute myocardial infarction (AMI), exacerbating myocardial ischemia and associated complications. This study explored the relationship between the C-reactive protein (CRP)-to-albumin (ALB) ratio (CRP/ALB) levels and the severity of coronary artery lesions and prognosis in 100 hypertensive patients with acute myocardial infarction. MATERIAL AND METHODS We enrolled 100 hypertensive patients with acute myocardial infarction and categorized them into different severity groups of coronary artery lesions based on coronary angiography results. Clinical data, including CRP and ALB levels, were collected, and the CRP/ALB ratio was calculated. Statistical methods were used to analyze the association between CRP/ALB ratio and the severity of coronary artery lesions. Patients were further divided into high and low CRP/ALB expression groups based on the median ratio value, and prognoses were compared. Kaplan-Meier survival curves and the log-rank test were used to assess adverse outcomes. RESULTS The CRP/ALB ratio significantly increased with the severity of coronary artery disease. Pearson correlation coefficient analysis demonstrated a significant positive correlation between the CRP/ALB ratio and the severity of coronary artery disease (P<0.05). Patients in the high CRP/ALB expression group had a significantly higher rate of unfavorable prognosis (40.00%) compared to those in the low expression group (16.00%) (P=0.008). The Kaplan-Meier (KM) survival curves for patients with high serum CRP/ALB expression shifted to the left compared to those with low expression, indicating poorer outcomes. CONCLUSIONS The CRP/ALB ratio is positively correlated with the severity of coronary artery disease. Higher serum CRP/ALB levels increase the risk of poor outcomes in hypertensive patients with AMI.