Quercetin Enhances GLP‐1 Secretion via TAS2R38‐Mediated PLC Signaling in Enteroendocrine L‐Cells

ABSTRACT Quercetin (QC), a natural flavonoid, has shown potential in regulating glucose homeostasis by promoting glucagon‐like peptide‐1 (GLP‐1) secretion. This study investigates the role of the bitter taste receptor TAS2R38 and the phospholipase C (PLC) signaling pathway in QC‐induced GLP‐1 secretion from enteroendocrine NCI‐H716 cells. Molecular docking revealed strong binding between QC and TAS2R38. QC significantly enhanced GLP‐1 secretion, which was attenuated by TAS2R38 siRNA and PLC inhibitors. These findings suggest that QC stimulates GLP‐1 release through TAS2R38‐mediated PLC signaling, offering a novel mechanism for QC's antidiabetic effects.