活性氧
氧化应激
癌变
超氧化物
DNA损伤
过氧化氢
癌症
化学
羟基自由基
致癌物
细胞凋亡
单线态氧
癌细胞
氧化磷酸化
细胞生物学
癌症研究
生物化学
生物
DNA
氧气
抗氧化剂
酶
遗传学
有机化学
作者
Payal Katakwar,Rashmi Metgud,Smitha Naik,Rashu Mittal
标识
DOI:10.4103/0973-1482.151935
摘要
Oxygen derived species such as hydrogen peroxide, superoxide anion radical, hydroxyl radical (OH-), and singlet oxygen are well known to be cytotoxic and have been implicated in the etiology of a wide array of human diseases, including cancer. Various carcinogens may also partly exert their effect by generating reactive oxygen species (ROS) during their metabolism. Oxidative damage to cellular DNA can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. ROS influences central cellular processes such as proliferation, apoptosis, and senescence which are implicated in the development of cancer. Understanding the role of ROS as key mediators in signaling cascades may provide various opportunities for pharmacological intervention.
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