A kind of gypsum block waterproofing agent is introduced,which is made of fluorine silicon modified aerylate resin and hardener.The modification effect of organic silicon and organic fluorine monomers on the water resistant of the waterproofing agent is researched.The waterproofing agent is respectively applied on gypsum block samples by coating or doping method.Effects of the agent on flexural strength,compressive strength and water absorption of gypsum block samples are studied.The experimental results show that the water absorption of gypsum block sample coated with waterproofing agent in water for 2h is significantly reduced;and the water absorption of gypsum block sample added waterproofing agent in water for 2h and 24h is also reduced,which softening coefficient reaches 0.71 for 24h,and fulfills the standard requirement of moisture resistant gypsum blocks.