Effects Of Different Concentrations Of Intraoperative Supplemental Oxygen On Post-Operative Nausea And Vomiting (PONV) In Patients Under Going Modified Radical Mastectomy

Postoperative Nausea and Vomiting (PONV) is a most common postoperative complication. Although regarded as a minor and often inevitable complication of anaesthesia and surgery it may delay discharge and necessitate hospital admission. It is an important cause of morbidity after anaesthesia. This study is aimed to know the effects of different concentrations of oxygen used intra-operatively on PONV in patients undergoing modified radical mastectomy. In a randomized and blinded study sixty patients receiving standardized general anaesthetic technique were randomly assigned to three groups, 20 patients in each. Group A receiving 30% oxygen intraoperatively. group B receiving 50% and group C receiving 80% oxygen respectively. The incidence of PONV and adverse events were recorded postoperatively up to 24 hrs. The incidence of PONV over 24 hrs after modified radical mastectomy showed no significant difference between all the three groups (p<0.05, one way ANOVA and chi square test). There was no significant difference in rescue antiemetics required between all groups. Conclusion: Intraperative high concentration of oxygen administration did not prevent PONV over the 24-hrs follow up period in patients undergoing modified radical mastectomy performed under general anaesthesia.