Levofloxacin- containing Sequential Therapy for Helicobacter Pylori Infection:Efficacy of Remedial Therapy

Objective To evaluate whether 10-day sequential therapy including esomeprazole,levofloxacinand,amoxicillin,amoxicillin, furazolidone and Lizhu Dele remedial therapy in Helicobacter pylori infection is better than 10-day standard quadruple therapy and the risk of adverse events between these two regimens. Methods Seventy-two Helicobacter pylori-positive patients with treatment failure of initial eradication were randomly divided into two groups:treatment group and control group,and the treatment group (37 patients)was treated with esomeprazole 20mg,levofloxacinand 200mg,amoxicillin 1000mg at first five days,orally two times a day at first five days and esomeprazole 20mg,levofloxacin 200mg,furazolidone 100mg and Lizhu Dele 220mg,orally two times a day at the second five days. The control group(35 patients)was treated with esomeprazole 20mg,levofloxacinand 200mg,furazolidone 100mg and tetracycline 750mg,orally two times a day for ten days. The incidence of adverse events during the medication was observed and Helicobacter pylori was detected 4 weeks after discontinuation. Results The eradication rate of the 10-day sequential therapy was 91.9% and that of the control group was 82.8%,with a significant difference between the two groups(P0.05). The incidence rat of adverse events of the 10-day sequential therapy was 10.8% and that of the control group was 22.9%,with a significant difference between the two groups (P0.05). Conclusion The sequential therapy in the composition of esomeprazole,levofloxacinand,amoxicillin,amoxicillin,furazolidone and Lizhu Dele is safe and more effective compared with standard quadruple therapy for re-eradicating Helicobacter pylori infection.