Plant cell wall is a complex which mainly consists of polysaccharides, proteins and lignin, and has been demonstrated to be widely involved in plant growth and development as well as in response to different abiotic and biotic stresses. Cell wall is the first barrier of heavy metal ions enter into the cytoplasm. The paper summarizes the roles of plant cell wall components, including the cell wall polysaccharides, proteins and lignin, in response to heavy metal stress and the mechanism of which involved in heavy metal tolerance, thus gives a better understanding of the roles of cell wall in plant heavy metal tolerance.