Research progress of multidrug resistance gene coded products in cervical cancer

Multidrug resistance is one of the most important factors influence the effectiveness of chemotherapy on cervical cancer.Lots of research reports on the causes of multi drugresistance are reported,mainly including following aspects:(1) Typical multidrug resistance:such as multidrug resistance gene 1(MDR1) and its coded protein as P-Glycoprotein(P-gp).The genes for multidrug resistance-associated protein(MRP) and lung resistance-related protein(LRP) and their coded protein over expression.(2)GST-π expression;(3) Non-typical multidrug resistance:the mechanism of Topo II induced resistance;(4) Inhibition by cell apoptosis(eg.Mutant P53 and cancer gene Her-2/neu/C-erbB-2 increased expressions) etc.By mutual influence and co-effectiveness,these factors caused the multidrug resistance.This report reviewed the researches and progress on products expressed from multidrug resistance genes in cervical cancer.