Utility of coagulation and fibrinolysis dynamicogram for detection of imbalance between coagulation and fibrinolysis in patient with sepsis

Objective To determine the role of coagulation and fibrinolysis dynamicogram(CF)in imbalance between coagulation and fibrinolysis from normality in sepsis.Methods Routine tests and CF were applied to detect the changes of coagulation and fibrinolysis for 24 patients with sepsis and 20 healthy individuals(control).The characteristic of routine tests and CF was analyzed by contrast during the changes of coagulation and fibrinolysis in the patients with sepsis.Results In routine test,compared with control individuls,there was statistically significant decurtation of prothrombin time(PT)and higher fibrinogen(Fbg)levels in the patients with sepsis,indicating there was hypercoagulation states in the patients with sepsis.Compared with control individuls,there were statistically significant higher D-dimer(D-D)and plasminogen(Plg)levels of routine parameters in the patients with sepsis,indicating there was hyperfinrinolysis state in the patients with sepsis.In CF,compared with control individuals,there was statistically significant decurtation of coagulation start time(CT)and coagulation start time(CST)and higher max extent(ME)and accelerating coagulation effect(ACE)levels of CF parameters in the patients with sepsis,indicating there was hypercoagulation state in the patients with sepsis.Although there was statistically significant prolonged fibrinolysis time(FT),statistically significant higher accelerating fibrinolysis effect(AFE)level in the patients with sepsis,indicating there was hyperfinrinolytic state in the patients with sepsis.Meanwhile,there were balance parameters in CF.Compared with control individuals,there were statistically significant higher balance level time(BLT),balance level exponent(BLE)levels(BLT,2.55±0.39,BLE 2.05±0.21)in sepsis than control(BLT,2.25±0.34,BLE 1.70±0.19).The findings indicated that there was imbalance state of coagulation and fibrinolysis and hypercoagulation state was a main factor between hypercoagulation and hyperfinrinolysis in the patients with sepsis.Conclusion Because there is both routine parameter and parameter of balance between coagulation and fibrinolysisi in CF,CF is more sensitive and specific than routine tests for differentiating imbalance between coagulation and fibrinolysis from normality in sepsis.