Molecular Epidemiology of Carbapenems-resistant Acinetobacter Baumannii

Objective To explore the gene homology of carbapenems-resistant Acinetobacter baumannii.Methods A total of 121 clinical isolated Acinetobacter baumannii were selected in the Fourth Affiliated Hospital of Guangzhou Medical University from January 2012 to September 2014.Agar dilution method was used to detect the drug resistance of carbapenems-resistant Acinetobacter baumannii to 14 kinds of commonly used antibiotics.Pulsed field gel electrophoresis was used to analyze the genotype of carbapenems-resistant Acinetobacter baumannii.Results Of the 121 carbapenems-resistant Acinetobacter baumannii,66 were carbapenems-sensitive Acinetobacter baumannii,55 were carbapenems-resistant Acinetobacter baumannii.Of the 55 carbapenems-resistant Acinetobacter baumannii,the drug resistant rate to minocyline was 40.0%,the drug resistant rates to other 13 commonly used antibiotics were all over 60.0%.A total of 8 genotypes were found in the 55carbapenems-resistant Acinetobacter baumannii,including A,B,C,D,E,F,G,H,and the A type is the most predominant one.Conclusion Carbapenems-resistant Acinetobacter baumannii are highly resistant to 14 kinds of commonly used antibiotics,and this hospital exist sporadic occurrence of carbapenems-resistant Acinetobacter baumannii.