静电纺丝
纳米纤维
伤口愈合
聚乙烯吡咯烷酮
材料科学
聚己内酯
纳米材料
再生(生物学)
双金属片
纳米颗粒
纳米技术
银纳米粒子
生物医学工程
化学工程
聚合物
复合材料
医学
高分子化学
外科
冶金
工程类
细胞生物学
金属
生物
作者
Mao Li,Min Hu,Honglian Zeng,Bo Yang,Yi Zhang,Ziwei Li,Lingeng Lu,Yue Ming
标识
DOI:10.1166/jbn.2021.3152
摘要
Native skin repair requires wound care products that not only protect the wound from bacterial infection, but also accelerate wound closure and minimize scarring. Nanomaterials have been widely applied for wound healing due to their multifunctional properties. In a previous study, we prepared and characterized electrospinning zinc oxide/silver/polyvinylpyrrolidone/polycaprolactone (ZnO/Ag/PVP/PCL) nanofibers using ZnO and Ag nanoparticles, and evaluated their antibacterial effect in vitro. In this work, further characterization studies were performed, which confirmed that the ZnO/Ag nanoparticles were physically embedded and evenly distributed in the ZnO/Ag/PVP/PCL nanofibers, enabling the sustained release of Ag and Zn. In addition, the bimetallic nanofibers showed satisfactory fluid handling and flexibility. In vivo wound healing and histology studies showed that the ZnO/Ag/PVP/PCL nanofibers had a better anti-inflammatory, skin tissue regeneration, and wound healing effect than monometallic nanofibers or a commercially available wound plaster (Yunnan Baiyao). Therefore, ZnO/Ag/PVP/PCL bimetallic nanofibers may be a safe, efficient biomedical dressing for wound healing.
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