区域选择性
化学
戒指(化学)
结构异构体
电泳剂
亲核细胞
催化作用
烷基
有机化学
组合化学
作者
Shrey P. Desai,Mark P. Taylor
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-08-30
卷期号:23 (18): 7049-7054
被引量:12
标识
DOI:10.1021/acs.orglett.1c02412
摘要
A method for regioselective ring openings of 3,4- and 2,3-epoxy alcohols with ambident nitrogen heterocycles is described. Using a diarylborinic acid catalyst, a single regioisomer is favored in couplings of nucleophile and electrophile partners that display low regioselectivity under conventional conditions. The method provides access to aromatic heterocycles bearing stereochemically defined, functionalized alkyl substituents, a product class similar in structure to medicinally relevant compounds such as the acyclic nucleoside analogues.
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