癌症治疗
纳米技术
生物相容性
免疫疗法
肽
药物输送
肿瘤微环境
癌症免疫疗法
纳米结构
癌症
材料科学
化学
医学
免疫系统
生物物理学
生物
生物化学
免疫学
内科学
冶金
作者
Masoud Delfi,Rossella Sartorius,Milad Ashrafizadeh,Esmaeel Sharifi,Yapei Zhang,Piergiuseppe De Berardinis,Ali Zarrabi,Rajender S. Varma,Franklin R. Tay,Smith Br,Pooyan Makvandi
出处
期刊:Nano Today
[Elsevier]
日期:2021-06-01
卷期号:38: 101119-101119
被引量:129
标识
DOI:10.1016/j.nantod.2021.101119
摘要
Self-assembled peptides and proteins possess tremendous potential as targeted drug delivery systems and key applications of these well-defined nanostructures reside in anti-cancer therapy. Peptides and proteins can self-assemble into nanostructures of diverse sizes and shapes in response to changing environmental conditions such as pH, temperature, ionic strength, as well as host and guest molecular interactions; their countless benefits include good biocompatibility and high loading capacity for hydrophobic and hydrophilic drugs. These self-assembled nanomaterials can be adorned with functional moieties to specifically target tumor cells. Stimuli-responsive features can also be incorporated with respect to the tumor microenvironment. This review sheds light on the growing interest in self-assembled peptides and proteins and their burgeoning applications in cancer treatment and immunotherapy.
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