Platelet-derived MMP-2 in the prevention of plaque formation: how many strokes is par?

Platelet-derived matrix metalloproteinase (MMP)-2 promotes early plaque formation in mice via activation of endothelial protease activated receptor (PAR)-1 and subsequent endothelial activation and monocyte intravasation. MMP-2 is overexpressed on the platelet surface in patients with coronary artery disease (CAD) and human immunodeficiency virus (HIV) compared with age- and sex-matched healthy controls. Platelet MMP-2 levels positively correlate with the degree of human carotid artery stenosis. This graphical abstract is based on the findings of Momi et al.10 and was created with Biorender.com.