Directed Evolution of Enantioconvergency: The Case of an Epoxide Hydrolase‐Catalyzed Reaction of a Racemic Epoxide

Highly evolved: The Aspergillus niger epoxide hydrolase (ANEH) has been subjected to laboratory evolution with the creation of mutants that transform the racemic epoxide to a single stereoisomer with greater than 90 % conversion and 99 % enantiomeric excess.