N-Halo Derivatives V: Comparative Antimicrobial Activity of Soft N-Chloramine Systems

Comparative antimicrobial activity studies for certain new classes of soft N-chloramines derived from α-aminoisobutyric acid and 2-amino-2-methyl-1-propanol were examined using the minimum inhibitory concentration (MIC) and/or the contact germicidal efficiency (CGE) procedures. Several factors significantly influence the antimicrobial activity of the soft N-chloramines: (a) the aliphatic chain length in a homologous series, (b) the degree of chlorination of the nitrogen atom, (c) the solution pH, (d) the presence of a denaturant, and (e) the nature of a positive charge.