自噬
内质网
未折叠蛋白反应
程序性细胞死亡
细胞生物学
细胞凋亡
癌症
癌症研究
癌细胞
生物
生物化学
遗传学
作者
Stephen M. Schleicher,Luigi Moretti,Vinod Varki,Bo Lü
标识
DOI:10.1016/j.drup.2010.04.002
摘要
Given the inherent resistance to apoptosis that characterizes cancer, the targeting of alternative pathways is an attractive strategy to improve anti-tumor therapy. Endoplasmic reticulum (ER) stress, which is basally activated in many cancers, and the subsequent activation of autophagy represent novel cancer treatment targets. While these associated pathways are often protective and promote cell survival, when excessive, ER stress results in autophagic cell death. Therefore, depending on the circumstances, either inhibition or activation of ER stress and autophagy can improve cancer therapy. This review provides an update on how ER stress relates to autophagy, and how these associated pathways can serve dual functions to promote survival or cell death in cancer. Furthermore, it lays out a spectrum of potential pharmacological agents and combinatorial approaches that target these pathways to enhance tumor cell kill.
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