Reprogramming Donor T cells for Adoptive Immunotherapy

重编程 过继免疫治疗 免疫疗法 过继性细胞移植 免疫学 癌症研究 医学 生物 T细胞 免疫系统 细胞 遗传学
作者
Markus Y. Mapara
出处
期刊:Immunotherapy [Future Medicine]
卷期号:5 (12): 1287-1289
标识
DOI:10.2217/imt.13.139
摘要

ImmunotherapyVol. 5, No. 12 CommentaryReprogramming donor T cells for adoptive immunotherapyMarkus Y MaparaMarkus Y MaparaDepartment of Medicine, Division of Hematoloy/Oncology & Columbia Center for Translational Immunology (CCTI), Columbia University, College of Physicians & Surgeons, 177Ft. Washington Avenue, MHB – 6GN435, New York, NY 10032, USA. Published Online:27 Nov 2013https://doi.org/10.2217/imt.13.139AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: GVHDmemoryPLZFT cellsReferences1 Barnes DW, Loutit JF. Treatment of murine leukaemia with x-rays and homologous bone marrow. II. Br. J. Haematol.3,241–252 (1957).Crossref, Medline, CAS, Google Scholar2 Horowitz MM, Gale RP, Sondel PM et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood75,555–562 (1990).Crossref, Medline, CAS, Google Scholar3 Gooley TA, Chien JW, Pergam SA et al. Reduced mortality after allogeneic hematopoietic-cell transplantation. N. Engl. J. Med.363,2091–2101 (2010).Crossref, Medline, CAS, Google Scholar4 Chen BJ, Cui X, Sempowski GD, Liu C, Chao NJ. Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease. Blood103,1534–1541 (2004).Crossref, Medline, CAS, Google Scholar5 Di Ianni M, Falzetti F, Carotti A et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood117,3921–3928 (2011).Crossref, Medline, CAS, Google Scholar6 Reddy P, Sun Y, Toubai T et al. Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice. J. Clin. Invest.118,2562–2573 (2008).Medline, CAS, Google Scholar7 Reddy P, Maeda Y, Hotary K et al. Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect. Proc. Natl Acad. Sci. USA101,3921–3926 (2004).Crossref, Medline, CAS, Google Scholar8 Leng C, Gries M, Ziegler J et al. Reduction of graft-versus-host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1. Exp. Hematol.34,776–787 (2006).Crossref, Medline, CAS, Google Scholar9 Reshef R, Luger SM, Hexner EO et al. Blockade of lymphocyte chemotaxis in visceral graft-versus-host disease. N. Engl. J. Med.367,135–145 (2012).Crossref, Medline, CAS, Google Scholar10 Kalos M, Levine BL, Porter DL et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci. Transl Med.3,95ra73 (2011).Crossref, Medline, CAS, Google Scholar11 Grupp SA, Kalos M, Barrett D et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N. Engl. J. Med.368,1509–1518 (2013).Crossref, Medline, CAS, Google Scholar12 Linette GP, Stadtmauer EA, Maus MV et al. Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma. Blood122,863–871 (2013).Crossref, Medline, CAS, Google Scholar13 Cameron BJ, Gerry AB, Dukes J et al. Identification of a titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells. Sci. Transl. Med.5,197ra103 (2013).Crossref, Medline, CAS, Google Scholar14 Vogtenhuber C, Bucher C, Highfill SL et al. Constitutively active Stat5b in CD4+ T cells inhibits graft-versus-host disease lethality associated with increased regulatory T-cell potency and decreased T effector cell responses. Blood116,466–474 (2010).Crossref, Medline, CAS, Google Scholar15 Ma H, Lu C, Ziegler J et al. Absence of Stat1 in donor CD4(+) T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice. J. Clin. Invest.121,2554–2569 (2011).Crossref, Medline, CAS, Google Scholar16 Ghosh A, Holland AM, Dogan Y et al. PLZF confers effector functions to donor T cells that preserve graft-versus-tumor effects while attenuating GVHD. Cancer Res.73,4687–4696 (2013).Crossref, Medline, CAS, Google Scholar17 Chen Z, Brand NJ, Chen A et al. Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J.12,1161–1167 (1993).Crossref, Medline, CAS, Google Scholar18 Suliman BA, Xu D, Williams BR. The promyelocytic leukemia zinc finger protein: two decades of molecular oncology. Front. Oncol.2,74 (2012).Crossref, Medline, Google Scholar19 Xu D, Holko M, Sadler AJ et al. Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity. Immunity30,802–816 (2009).Crossref, Medline, CAS, Google Scholar20 Kovalovsky D, Uche OU, Eladad S et al. The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nat. Immunol.9,1055–1064 (2008).Crossref, Medline, CAS, Google Scholar21 Kovalovsky D, Alonzo ES, Uche OU, Eidson M, Nichols KE, Sant'Angelo DB. PLZF induces the spontaneous acquisition of memory/effector functions in T cells independently of NKT cell-related signals. J. Immunol.184,6746–6755 (2010).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Vol. 5, No. 12 Follow us on social media for the latest updates Metrics Downloaded 33 times History Published online 27 November 2013 Published in print December 2013 Information© Future Medicine LtdKeywordsGVHDmemoryPLZFT cellsFinancial & competing interests disclosureThis work was supported by the NIH RO1 HL093716. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
SciGPT应助科研通管家采纳,获得10
1秒前
会飞的猪发布了新的文献求助10
1秒前
NexusExplorer应助科研通管家采纳,获得10
1秒前
彭于晏应助科研通管家采纳,获得10
1秒前
2秒前
英姑应助科研通管家采纳,获得10
2秒前
烟花应助科研通管家采纳,获得10
2秒前
英俊的铭应助123456采纳,获得10
2秒前
Ava应助科研通管家采纳,获得10
2秒前
从容芮应助科研通管家采纳,获得10
2秒前
科研通AI2S应助科研通管家采纳,获得10
2秒前
CipherSage应助科研通管家采纳,获得10
2秒前
2秒前
2秒前
2秒前
科研通AI5应助科研通管家采纳,获得10
2秒前
Ambi发布了新的文献求助30
2秒前
橘子发布了新的文献求助30
3秒前
3秒前
Lucas应助文艺的匪采纳,获得10
5秒前
舒伯特完成签到 ,获得积分10
5秒前
ffffffff发布了新的文献求助10
6秒前
CS完成签到,获得积分20
9秒前
9秒前
周周发布了新的文献求助10
9秒前
高高哑铃发布了新的文献求助10
10秒前
洁净路灯完成签到,获得积分10
10秒前
鲨鱼青椒发布了新的文献求助20
10秒前
小马甲应助嗯嗯采纳,获得10
10秒前
13秒前
123456发布了新的文献求助10
14秒前
居糯糯完成签到,获得积分10
15秒前
量子星尘发布了新的文献求助10
16秒前
16秒前
sss发布了新的文献求助10
17秒前
17秒前
rr完成签到,获得积分10
18秒前
18秒前
20秒前
高分求助中
【提示信息,请勿应助】请使用合适的网盘上传文件 10000
The Oxford Encyclopedia of the History of Modern Psychology 1500
Green Star Japan: Esperanto and the International Language Question, 1880–1945 800
Sentimental Republic: Chinese Intellectuals and the Maoist Past 800
The Martian climate revisited: atmosphere and environment of a desert planet 800
Parametric Random Vibration 800
Electron microscopy study of magnesium hydride (MgH2) for Hydrogen Storage 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3865360
求助须知:如何正确求助?哪些是违规求助? 3407621
关于积分的说明 10655266
捐赠科研通 3131725
什么是DOI,文献DOI怎么找? 1727276
邀请新用户注册赠送积分活动 832220
科研通“疑难数据库(出版商)”最低求助积分说明 780189