A novel dual-signal molecularly imprinted electrochemical sensor based on NiFe prussian blue analogue and SnS2 for detection of p-Hydroxyacetophenone

Herein, based on the dual-signal strategy, an electrochemical sensor with molecularly imprinted polymer (MIP) was designed for the analysis of p-Hydroxyacetophenone (p-HAP) for the first time. The sensor was fabricated by modifying the electrode with NiFe prussian blue analogue (NiFe-PBA) and followed by SnS2, obtaining the dual-signal from [Fe(CN)6]3−/4− at 0.20 V and NiFe-PBA at 0.52 V. In the electropolymerization of the MIP film, o-phenylenediamine was used as functional monomer and p-HAP acted as template molecule. After the adsorption of p-HAP, the two above oxidation peak currents decreased simultaneously compared with the elution, achieving the dual-signal analysis. Under the optimal conditions, the sensor exhibited a wide linear range of 10−13 M to 10−7 M and a low detection limit of 3.52 × 10−14 M (3σ). Moreover, it was successfully applied to the p-HAP detection in human serum and environment water samples with satisfactory recovery.