材料科学
发光
纳米颗粒
乙二醇
胰岛
马来酸酐
镱
核化学
共聚物
核磁共振
兴奋剂
纳米技术
聚合物
光电子学
胰岛素
化学
小岛
有机化学
内分泌学
复合材料
物理
医学
作者
Oleksandr Shapoval,Hana Engstová,Daniel Jirák,Jan Drahokoupil,Kateřina Sulková,Zuzana Berková,Ognen Pop‐Georgievski,Blanka Holendová,Petr Ježek,Daniel Horák
标识
DOI:10.1021/acsami.2c04274
摘要
Novel Yb,Tb,Nd-doped GdF3 and NaGdF4 nanoparticles were synthesized by a coprecipitation method in ethylene glycol (EG) in the presence of the poly(4-styrenesulfonic acid-co-maleic anhydride) stabilizer. The particle size and morphology, crystal structure, and phase change were controlled by adjusting the PSSMA concentration and source of fluoride anions in the reaction. Doping of Yb3+, Tb3+, and Nd3+ ions in the NaGdF4 host nanoparticles induced luminescence under ultraviolet and near-infrared excitation and high relaxivity in magnetic resonance (MR) imaging (MRI). In vitro toxicity of the nanoparticles and their cellular uptake efficiency were determined in model rat pancreatic β-cells (INS-1E). As the NaGdF4:Yb,Tb,Nd@PSSMA-EG nanoparticles were non-toxic and possessed good luminescence and magnetic properties, they were applicable for in vitro optical and MRI of isolated pancreatic islets in phantoms. The superior contrast was achieved for in vivoT2*-weighted MR images of the islets transplanted under the kidney capsule to mice in preclinical trials.
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