Ferulic Acid Integrated Non‐Invasive Microneedle Patches for Localized Bruising Treatment

Abstract Medicinal plasters have obvious value in promoting blood circulation and removing blood stasis, while their practical values are usually restricted by the skin barrier, resulting in lower local drug concentration and unsatisfactory therapeutic efficacy. Here, a novel non‐invasive microneedle patch coated with ferulic acid Chinese herbal plasters (FA@MNs) is presented for the treatment of localised bruising and swelling. The FA@MNs consists of a pyramid‐shaped blunt microneedle array core fabricated by poly(ethylene glycol) diacrylate (PEGDA) and traditional Chinese herbal plaster coating composed of ferulic acid and carbomer gel. This special design of microneedles can non‐invasively open the skin barrier, enabling more efficient drug delivery while avoiding potential skin damage. Besides, the traditional Chinese herbal plaster coated in microneedle arrays provides further adhesion to the skin surface. It has been demonstrated that the FA@MNs could effectively reduce blood viscosity and inflammatory response in rats while ensuring skin tissue integrity. These results certify that the novel non‐invasive microneedle patch has great potential in improving the effects of clinical medicinal plasters.