Epigenetic Regulation of Cholesterol and Oxysterol Homeostasis

The epigenetic regulation of genes involved in cholesterol and oxysterol homeostasis is an emerging field with significant potential for elucidating the association between sterol homeostasis and diseases. DNA, RNA, histone modifications, as well as non-coding RNA, regulate cholesterol and oxysterol homeostasis by coordinating pathways involved in cholesterol synthesis, uptake, efflux, and alterations in metabolites. Therefore, dysregulation of epigenetic modifications may have important implications for the pathogenesis of cholesterol and oxysterol metabolism disorders. Here, we review recent advances in the function and mechanism of the interaction between cholesterol/oxysterol metabolism regulation and epigenetic modifications to discuss how each of the 4 parts of cholesterol metabolism is executed and regulated with the participation of epigenetic modification.