The effect of cognition on the association between cerebral small vessel disease burden and motor function: a cross-sectional study

The CSVD burden influences both SPPB score and knee ROM in patients with mild to moderate cognitive and motor impairments, either directly or indirectly through cognitive decline. Cognitive function, as measured by the MoCA score, plays a significant mediating role in the association between CSVD burden and both SPPB score and knee ROM.