Synergistic Copper‐Coordination/Glutathione Reduction Drives an In Situ Type II‐to‐Type I Photodynamic Switch in Iridium‐Based Photosensitizer Nanocomposites for Potentiated Cancer Immunotherapy

) under light irradiation. Mechanistic studies reveal that Ir1@FA@MOFs orchestrate multimodal cell death induction including cuproptosis, ferroptosis, and PANoptosis through mitochondrial damage. In 4T1 tumor-bearing mice, Ir1@FA@MOFs demonstrate high tumor growth inhibition while converting "cold" tumors to immunogenic hotspots. The work pioneers a TME-responsive photodynamic modality switching strategy that overcomes traditional PDT limitations through metal-coordination and GSH-activating immunogenic death programming, offering new dimensions for precision photo-immunotherapy.