Aldosterone Synthase Inhibition for Hypertension

Hypertension is described as resistant if a patient who is taking three or more antihypertensive agents, including a diuretic, at the maximum recommended doses maintains a blood pressure of 140/90 mm Hg or more during an office visit, after pseudo-resistance and secondary causes have been excluded.1 This condition affects nearly 1 in 10 patients with hypertension1 and carries a disproportionate global burden of cardiovascular risk.2,3 In many cases, resistant hypertension represents a salt-retaining, low-renin state driven by inappropriate, renin-independent aldosterone secretion. An excess of aldosterone drives sodium and water retention, along with fibrosis, inflammation, and vascular injury, which amplifies the . . .