LGR5型
干细胞
Wnt信号通路
肠粘膜
生物
溃疡性结肠炎
成体干细胞
细胞生物学
潘尼斯电池
癌症研究
免疫学
细胞分化
病理
信号转导
医学
小肠
癌症干细胞
内科学
内分泌学
疾病
生物化学
基因
作者
Lie Zheng,Sheng-Lei Duan
标识
DOI:10.3748/wjg.v29.i16.2380
摘要
Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with complex causes. The main pathological changes were intestinal mucosal injury. Leucine-rich repeat-containing G protein coupled receptor 5 (LGR5)-labeled small intestine stem cells (ISCs) were located at the bottom of the small intestine recess and inlaid among Paneth cells. LGR5+ small ISCs are active proliferative adult stem cells, and their self-renewal, proliferation and differentiation disorders are closely related to the occurrence of intestinal inflammatory diseases. The Notch signaling pathway and Wnt/β-catenin signaling pathway are important regulators of LGR5-positive ISCs and together maintain the function of LGR5-positive ISCs. More importantly, the surviving stem cells after intestinal mucosal injury accelerate division, restore the number of stem cells, multiply and differentiate into mature intestinal epithelial cells, and repair the damaged intestinal mucosa. Therefore, in-depth study of multiple pathways and transplantation of LGR5-positive ISCs may become a new target for the treatment of UC.
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