Serum fat-soluble vitamin levels may be related to sudden sensorineural hearing loss

AbstractBackground Few related studies reported yet the association between vitamins and the onset of sudden sensorineural hearing loss (SSNHL).Objective To explore the relationship between the serum levels of fat-soluble vitamins A, D, and E and the risk of SSNHL.Methods This retrospective analysis included 310 SSNHL patients and 154 people without risk of hearing loss. The demographic information of all participants like age, gender, body mass index, occupation, cigarette smoking or drinking status, etc. were recorded. The serum levels of vitamins A, D, and E were determined using the electrochemical method.Results The results indicated that serum vitamin D levels in SSNHL patients were significantly lower. Vitamin D deficiency was only observed in SSNHL group. Similarly, serum vitamin A levels in female SSNHL patients were significantly lower than the control group. Meanwhile, serum vitamin E levels in male SSNHL patients were significantly lower than the control group.Conclusion and significance Our results revealed that the serum levels of fat-soluble vitamins A, D, and E in SSNHL patients were lower than those in the control group with normal hearing, indicating that the decrease of serum fat-soluble vitamins may be related to SSNHL pathogenesis.Chinese abstract背景：关于维生素与突发性感音神经性听力损失（SSNHL）发作之间的关联的研究报道很少。目的：探讨脂溶性维生素A、D、E的血清水平与SSNHL 风险的关系。方法：这项回顾性分析包括 310 名 SSNHL 患者和 154 名无听力损失风险的人。 记录了所有参与者的人口统计信息, 如年龄、性别、体重指数、职业、吸烟或饮酒情况等。维生素A、D、和 E 的血清水平是使用电化方法测定的。结果：结果表明, SSNHL 患者的血清维生素 D 水平低很多。只在 SSNHL 组中观察到维生素 D 缺乏症。 同样, 女性SSNHL患者血清维生素 A 水平明显低于对照组。 同时, 男性SSNHL患者的血清维生素 E 水平明显低于对照组。结论和意义：我们的结果表明, SSNHL 患者的脂溶性维生素 A、D、和 E的血清水平 低于听力正常的对照组。这说明血清脂溶性维生素的减少可能与SSNHL的发病机制有关。Keywords: Sudden sensorineural hearing lossfat-soluble vitaminsvitamin Avitamin Dvitamin Ecorrelation Disclosure statementNo potential conflict of interest was reported by the author(s).