The prognostic value of the modified Glasgow Prognostic Score in the management of patients with chondrosarcoma

Aims The prognostic role of systemic inflammatory biomarkers in patients with chondrosarcoma remains unclear, and evidence is lacking. The modified Glasgow Prognostic Score (mGPS) is an inflammation-based prognostic score consisting of preoperative CRP and albumin. This has been validated for a number of carcinomas and soft-tissue sarcoma, where its use is recommended. This national multicentre study aimed to investigate the prognostic significance of preoperative systemic inflammatory biomarkers, primarily the mGPS, in the prediction of survival in patients with a chondrosarcoma. Methods Patients who had undergone an elective resection of a primary or secondary chondrosarcoma between January 2006 and December 2020 were identified from the prospectively maintained databases of seven collaborating UK bone sarcoma units. Laboratory and clinical data, as well as oncological outcomes, were collected from the patient records with a minimum of two years of follow-up. Data were analyzed using Kaplan-Meier survival and uni- and multivariate analysis. Results A total of 549 patients were included in our study. We found that increased mGPS, tumour grade, size, age, local recurrence, metastasis, and inflammatory markers were significantly associated with reduced overall survival. mGPS was able to stratify the overall survival of patients in all grades of chondrosarcoma, especially when divided into mGPS score 0 versus mGPS 1 or 2. Conclusion Our findings indicate that inflammatory markers and mGPS strongly correlate with the survival of patients with a chondrosarcoma. We recommend its use in their early assessment to better stratify prognosis, reinforce decision-making, and potentially improve outcomes. Cite this article: Bone Joint J 2025;107-B(6):649–656.