化学
钌
芳基
催化作用
药物化学
烷基
分子
立体化学
组合化学
有机化学
标识
DOI:10.1002/ajoc.202300384
摘要
Abstract The [Ru( p ‐cymene)Cl 2 ] 2 ‐catalyzed reaction of 2‐arylpyridines with 1‐aryl‐2‐vinylpyrrolidines is carried out in CF 3 CH 2 OH at 40 °C in the presence of KOAc, affording ortho ‐C−H allylation products of arenes in 29 % to 99 % yields and 1:0.7 to 1 : 5.4 Z / E ratio. The amino groups remain in the product molecules. The protocol suits for a wide scope of substrates and tolerates functional groups including alkyl, aryl, MeO, F, Cl, Br, OCF 3 , and CF 3 groups.
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