Metal-organic framework Ce-TCPP with multimodal therapy properties under laser induction

The photosensitiser H4TCPP and cerium ion with chemodynamic therapeutic effect was selected to prepare a porphyrin-based metal-organic framework Ce-TCPP. To increase the therapeutic functions of the material, Mn2+ and indocyanine green (ICG) were loaded into Ce-TCPP to construct the multimodal therapy system ICG&Mn@Ce-TCPP (ICG: 55.36 wt%, Mn2+: 1.15 wt%). The introduction of Mn2+ improved the chemodynamic therapeutic effects. Under the 808 nm/660 nm laser irradiation, the system displayed excellent photothermal stability, good photothermal conversion efficiency (η=53.32%) and the capacity to generate highly cytotoxic singlet oxygen (1O2) which related with photodynamic therapy. Comparing with Ce-TCPP, Mn2+ and ICG enhanced the growth inhibitory effect of the material system on B16 cells, and the inhibitory effect of ICG&Mn@Ce-TCPP was further improved under laser irradiation. The results demonstrated that ICG&Mn@Ce-TCPP had promised potential for achieving simultaneous chemodynamic/photothermal/photodynamic therapy under laser irradiation.