移植
造血
环磷酰胺
脐带血
干细胞
医学
移植嵌合体
造血干细胞移植
血液学
免疫学
造血细胞
肿瘤科
化疗
内科学
生物
遗传学
作者
Tomoyasu Jo,Tomoaki Ueda,Yu Akahoshi,Tadakazu Kondo,Naoyuki Uchida,Masatsugu Tanaka,Hirohisa Nakamae,Noriko Doki,Shuichi Ota,Masashi Sawa,Hiroyuki Ohigashi,Yumiko Maruyama,Nobuki Takayama,Tetsuya Nishida,Nobuhiro Hiramoto,Yuta Katayama,Yoshinobu Kanda,Tatsuo Ichinohe,Yoshiko Atsuta,Yasuyuki Arai
摘要
Summary To assess the benefits of HLA‐haploidentical haematopoietic stem cell transplantation using post‐transplant cyclophosphamide (PTCy‐haplo) relative to those of umbilical cord blood (UCB) transplantation in acute lymphoblastic leukaemia (ALL), we analysed 1999 patients (PTCy‐haplo, 330; UCB, 1669), using the nationwide Japanese registry. PTCy‐haplo was associated with a significantly higher relapse rate, but lower non‐relapse mortality, which results in overall survival and disease‐free survival, comparable to those of UCB. Among patients in CR1, PTCy‐haplo showed a significantly higher survival than UCB regardless of the CD34 + cell dose. Our findings provide valuable insights into the donor selection algorithm in allogeneic HSCT for adult patients with ALL.
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