涂层
生物相容性
材料科学
钛
表面改性
植入
核化学
化学工程
生物医学工程
复合材料
冶金
化学
医学
外科
工程类
作者
Guobo Lan,Xiao Chu,Chaohui Li,Chi Zhang,Guiqiang Miao,Wenyong Li,Feng Peng,Xiaodong Zhao,Mei Li
标识
DOI:10.1088/1748-605x/ac9e33
摘要
Peri-implant infection remains one of the greatest threats to orthopedics. The construction of bone implants with good antibacterial and osteogenic properties is beneficial for reducing the risk of implant-related infections and healing bone defects. In this study, N-halamine coating (namely N-Cl) was grafted onto alkali-heat treated titanium (Ti) using polydopamine to endow Ti-based orthopedic implants with strong bactericidal activity. Surface characterization revealed that the N-Cl coating has porous structure loaded with active chlorine (Cl+). The N-Cl coating also provided micro/nano-structured Ti surfaces with excellent antibacterial ability via transformation between N-H and N-Cl, and approximately 100% disinfection was achieved. Furthermore, the as-prepared N-Cl coating exhibited good biocompatibility and osteogenesis abilityin vitro. These results indicate that applying N-Cl coatings on Ti could prevent and treat peri-implant infections.
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