Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

Anti-tumor immunity is limited by reduced T cell persistence and antigen presentation. Denk et al. show that Urolithin A, a natural metabolite of pomegranate extract, enhances antigen presentation in cancer and promotes mitophagy in CD8 + T cells, resulting in generation regenerative stem cell-like memory (T SCM ) cells with enhanced antitumor properties.