Synthesis of Chiral Cyclopentadienyl Rhodium Complexes and Their Application in Enantioselective C–H Functionalization Reactions

Abstract In recent years, rhodium catalysis has evolved as a powerful tool for chemo- and stereocontrolled syntheses of chiral molecules through C–H functionalization. In particular, chiral cyclopentadienyl rhodium (CpRh) complex-catalyzed asymmetric C–H functionalization reactions have gained ever-increasing attention in organic synthesis. However, the design and synthesis of novel chiral Cp ligands remain challenging due to the difficulty of imparting chiral elements into the Cp moiety. In this account, we introduce our research progress in the syntheses of chiral cyclopentadienyl ligands and their applications in rhodium-catalyzed asymmetric C–H functionalization reactions. 1 Introduction 2 SCpRh-Catalyzed Enantioselective C–H Functionalization Reactions 3 CpmRh-Catalyzed Enantioselective C–H Functionalization Reactions 4 BOCpRh-Catalyzed Enantioselective C–H Functionalization Reactions 5 BCSCpRh-Catalyzed Enantioselective C–H Functionalization Reactions 6 Conclusion