Plant-based Adjuvant in Vaccine Immunogenicity: A Review

Background: The problem of poor immunogenicity of new generation vaccines has generated the need for more effective and safe adjuvants for inducing a seroprotective immune response. Objective and Method: The plant-based immunoadjuvants have the potential to promote an optimized immune response and are promising candidate adjuvants for novel vaccine development. There are many natural compounds, which exhibit vaccine adjuvant activity. However, safety and hemolytic toxicity remain a problem. Research in the last four decades shows that plant extracts can be screened for isolating the least toxic adjuvant. Plant-based adjuvants with their superior immunostimulatory property could provide us with an effective alternative to conventional adjuvants. Conclusion: The present paper enumerates the plant-based immunoadjuvant which has shown remarkable immunostimulatory properties. Keywords: Haemolytic, immunoadjuvant, ovalbumin, polysaccharide, saponins, splenocyte.