纳米棒
免疫佐剂
佐剂
材料科学
分泌物
CD86
体内
免疫系统
纳米技术
兴奋剂
化学工程
化学
免疫学
T细胞
生物
生物化学
生物技术
工程类
光电子学
作者
Xiupeng Wang,Shu Ihara,Xia Li,Atsuo Ito,Yu Sogo,Yohei Watanabe,Noriko M. Tsuji,Atsushi Yamazaki
标识
DOI:10.1016/j.colsurfb.2018.11.026
摘要
Recombinant protein-based vaccines generally show limited immunogenicity and need adjuvants to achieve robust immune responses. Herein, to combine the excellent biocompatibility of hydroxyapatite (HA) and exciting adjuvant activity of silica, Si-doped HA nanorods with Si/P molar ratio from 0 to 0.65 were hydrothermally synthesized and evaluated as immunoadjuvants. Si-doping decreases the size and increases the BET surface area of the nanorods. Si-doping in HA nanorods increases the in vitro adjuvant activity, including CD11c+CD86+ expression and cytokine secretion of bone marrow derived dendritic cells (BMDCs). Moreover, Si-doping in HA increases the ex vivo adjuvant activity as shown by the increase in both Th1 and Th2 cytokines secretion. Si-doped HA nanorods are promising as a new immunoadjuvant.
科研通智能强力驱动
Strongly Powered by AbleSci AI