生物物理学
伤口愈合
光热效应
光敏剂
生物医学工程
体内
材料科学
生物相容性
金黄色葡萄球菌
膜
光动力疗法
辐照
作者
Li Mu,Xiangmei Liu,Lei Tan,Zhenduo Cui,Xianjin Yang,Zhaoyang Li,Yufeng Zheng,Kelvin W.K. Yeung,Paul K. Chu,Shuilin Wu
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2018-07-24
卷期号:6 (8): 2110-2121
被引量:91
摘要
Bacterial infection often delays healing of wounded tissues and so it is essential to improve the antibacterial efficiency in situ. In this work, a hybrid hydrogel composed of 3-(trimethoxysilyl)propyl methacrylate (MPS, 97%) and mesoporous silica (mSiO2) modified CuS nanoparticles (NPs) is synthesized by radical polymerization. The materials possess excellent and controllable photothermal and photodynamic properties under 808 nm near-infrared (NIR) light irradiation as well as an antibacterial efficacy of 99.80% and 99.94% against Staphylococcus aureus and Escherichia coli within 10 min, respectively. The excellent performance stems from the combined effects of hyperthermia, radical oxygen species, and released copper ions produced during NIR irradiation of CuS NPs. Moreover, the released copper ions stimulate fibroblast proliferation and angiogenesis and the intrinsic volume transition of the hydrogel composed of N-isopropylacrylamide (NIPAAm) and acrylamide (AAm) controls the release rate of copper ions during NIR light irradiation leading to both antibacterial effects and skin tissue regeneration.
科研通智能强力驱动
Strongly Powered by AbleSci AI