Precise microfluidic engineering of mRNA lipid nanoparticle-loaded polycaprolactone microcapsules for sustained delivery

studies demonstrated that mRNA LNP-loaded microcapsules significantly extended the retention time of mRNA in mice, maintaining mRNA expression for up to 8 days following a single injection. These findings highlight the potential of this microcapsule-based delivery system for long-lasting mRNA delivery, improving both therapeutic efficacy and patient compliance.