重编程
癌症研究
肿瘤微环境
肝内胆管癌
生物标志物
生物
免疫系统
计算生物学
癌症
信号转导
细胞生物学
肿瘤细胞
免疫逃逸
细胞生长
细胞
作者
Xiaoxiang Rong,Jiayun Guan,Chanqi Ye,Qiong Li,Mingyu Wan,Wenguang Fu,Jinzhang Chen,Dayong Zheng,Ru-Yin Chen,Rui Zhou,Gautam Sethi,Yunlu Jia,Jian Ruan
标识
DOI:10.1016/j.jare.2025.11.011
摘要
Our findings uncover a novel SPINK1-CCL20-LAMs axis that orchestrates immune recruitment and metabolic reprogramming in ICC. SPINK1 facilitates tumor growth by establishing a glutamine-rich microenvironment via LAMs. These insights highlight SPINK1 as a potential therapeutic target and prognostic biomarker in ICC.
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