化学
光动力疗法
癌症治疗
肿瘤微环境
癌症治疗
重症监护医学
医学
癌症
纳米技术
计算机科学
癌症研究
材料科学
肿瘤细胞
内科学
有机化学
作者
Linye Jiang,Libing Liu,Fengting Lv,Shu Wang,Xueqin Ren
标识
DOI:10.1002/cplu.202000083
摘要
Abstract Photodynamic therapy (PDT), as an emerging clinical approach, has been exploited for the treatment of various diseases including cancer for several years. Excitation light and molecular oxygen are the key parameters that restrict the efficacy of PDT due to the restricted penetration depth of light and the hypoxic microenvironment of tumors, which will lead to ineffective therapeutic response. In recent years, a number of studies were focused on tackling these challenges and showed great potential in improving the efficacy of PDT to some degree. Herein, we summarize the advancements in newly developed PDT strategies based on diverse nanocomposites, especially in the aspects of the types of light source and the ways to supply oxygen. Finally, new challenges and possible opportunities for further research are also discussed.
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