Visible-Light Mediated ortho-Trifluoromethylation of Aniline Derivatives

A general visible-light mediated ortho -C–H trifluoromethylation of aniline derivatives by using a low-cost and stable Langlois reagent (CF 3 SO 2 Na) as the “CF 3 ” source has been developed. In contrast to previous reports, this strategy allowed access to elusive trifluoromethyl lactams. Furthermore, mechanism experiments revealed that a copper/photoredox dual catalytic mechanism enabled general trifluoromethylation of aniline derivatives.