Status and development on relationship between matrix metalloproteinase-2, matrix metalloproteinase-9 and occurrence and invasion metastasis of lung cancer

Matrix metalloproteinases (MMPs) are also known as matrixins.Many diseases,such as osteoarthritis,multiple sclerosis,and cancer,are accompanied by changes of activity of MMPs.MMPs play roles in invasion and metastasis of malignant tumors.This article reviews the status and development on relationship between MMP-2,MMP-9 and the occurrence and metastasis of lung cancer. Key words: Matrix metalloproteinases;  Lung cancer;  Matrix metalloproteinase-2;  Matrix metalloproteinase-9