坏死性下垂
程序性细胞死亡
上睑下垂
细胞凋亡
自噬
癌细胞
癌症研究
细胞
癌症
UVB诱导细胞凋亡
生物
细胞生物学
半胱氨酸蛋白酶
生物化学
遗传学
作者
Jing Ye,Ruonan Zhang,Fan Wu,Li Zhai,Kaifeng Wang,Mang Xiao,Tian Xie,Xinbing Sui
标识
DOI:10.1016/j.canlet.2018.01.061
摘要
Traditional cancer therapy is mainly targeting on enhancing cell apoptosis, however, it is well established that many cancer cells are chemo-resistant and defective in apoptosis induction. Therefore, it may have important therapeutic implications to exploit some novel natural compounds based on non-apoptotic programmed cell death. Currently, accumulating evidence shows that the compounds from nature source can induce non-apoptotic programmed cell death in cancer cells, and therefore these natural compounds have gained a great promise for the future anticancer therapeutics. In this review, we will concentrate our efforts on the latest developments regarding major forms of non-apoptotic programmed cell death--autophagic cell death, necroptosis, ferroptosis, pyroptosis, glutamoptosis and exosome-associated cell death. Our increased understanding of the role of natural compounds in regulating non-apoptotic programmed cell death will hopefully provide prospective strategies for cancer therapy.
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