Membrane curvature as a signal to ensure robustness of diverse cellular processes

An increasing corpus of research has demonstrated that membrane shape, generated either by the external environment of the cell or by intrinsic mechanisms such as cytokinesis and vesicle or organelle formation, is an important parameter in the control of diverse cellular processes. In this review we discuss recent findings that demonstrate how membrane curvature (from nanometer to micron length-scales) alters protein function. We describe an expanding toolkit for experimentally modulating membrane curvature to reveal effects on protein function, and discuss how membrane curvature – far from being a passive consequence of the physical environment and the internal protein activity of a cell – is an important signal that controls protein affinity and enzymatic activity to ensure robust forward progression of key processes within the cell.