清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Cervical Cancer Screening

医学 阴道镜检查 鳞状上皮内病变 宫颈癌 子宫颈 巴氏染色 妇科 人口 宫颈上皮内瘤变 癌症 肿瘤科 内科学 产科 环境卫生
作者
Rebecca B. Perkins,Nicolas Wentzensen,Richard S. Guido,Mark Schiffman
出处
期刊:JAMA [American Medical Association]
卷期号:330 (6): 547-547 被引量:184
标识
DOI:10.1001/jama.2023.13174
摘要

Each year in the US, approximately 100 000 people are treated for cervical precancer, 14 000 people are diagnosed with cervical cancer, and 4000 die of cervical cancer.Essentially all cervical cancers worldwide are caused by persistent infections with one of 13 carcinogenic human papillomavirus (HPV) genotypes: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68. HPV vaccination at ages 9 through 12 years will likely prevent more than 90% of cervical precancers and cancers. In people with a cervix aged 21 through 65 years, cervical cancer is prevented by screening for and treating cervical precancer, defined as high-grade squamous intraepithelial lesions of the cervix. High-grade lesions can progress to cervical cancer if not treated. Cervicovaginal HPV testing is 90% sensitive for detecting precancer. In the general population, the risk of precancer is less than 0.15% over 5 years following a negative HPV test result. Among people with a positive HPV test result, a combination of HPV genotyping and cervical cytology (Papanicolaou testing) can identify the risk of precancer. For people with current precancer risks of less than 4%, repeat HPV testing is recommended in 1, 3, or 5 years depending on 5-year precancer risk. For people with current precancer risks of 4% through 24%, such as those with low-grade cytology test results (atypical squamous cells of undetermined significance [ASC-US] or low-grade squamous intraepithelial lesion [LSIL]) and a positive HPV test of unknown duration, colposcopy is recommended. For patients with precancer risks of less than 25% (eg, cervical intraepithelial neoplasia grade 1 [CIN1] or histologic LSIL), treatment-related adverse effects, including possible association with preterm labor, can be reduced by repeating colposcopy to monitor for precancer and avoiding excisional treatment. For patients with current precancer risks of 25% through 59% (eg, high-grade cytology results of ASC cannot exclude high-grade lesion [ASC-H] or high-grade squamous intraepithelial lesion [HSIL] with positive HPV test results), management consists of colposcopy with biopsy or excisional treatment. For those with current precancer risks of 60% or more, such as patients with HPV-16-positive HSIL, proceeding directly to excisional treatment is preferred, but performing a colposcopy first to confirm the need for excisional treatment is acceptable. Clinical decision support tools can facilitate correct management.Approximately 100 000 people are treated for cervical precancer each year in the US to prevent cervical cancer. People with a cervix should be screened with HPV testing, and if HPV-positive, genotyping and cytology testing should be performed to assess the risk of cervical precancer and determine the need for colposcopy or treatment. HPV vaccination in adolescence will likely prevent more than 90% of cervical precancers and cancers.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
房天川完成签到 ,获得积分10
刚刚
小西完成签到 ,获得积分10
3秒前
一颗红葡萄完成签到 ,获得积分10
6秒前
苗条丹南完成签到 ,获得积分10
9秒前
qq完成签到 ,获得积分10
9秒前
41秒前
49秒前
51秒前
wxyinhefeng完成签到 ,获得积分10
57秒前
1分钟前
啾啾发布了新的文献求助10
1分钟前
1分钟前
然而。完成签到 ,获得积分10
1分钟前
孙老师完成签到 ,获得积分10
1分钟前
啾啾完成签到,获得积分10
1分钟前
六等于三二一完成签到 ,获得积分10
2分钟前
不如看海完成签到 ,获得积分10
2分钟前
Hello应助专注的月亮采纳,获得10
2分钟前
2分钟前
2分钟前
专注的月亮完成签到,获得积分10
2分钟前
Skywings发布了新的文献求助10
3分钟前
牛八先生完成签到,获得积分10
3分钟前
老张完成签到 ,获得积分10
3分钟前
Nancy0818完成签到 ,获得积分10
3分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
NexusExplorer应助枯藤老柳树采纳,获得10
3分钟前
鸢翔flybird完成签到,获得积分10
3分钟前
3分钟前
微解感染发布了新的文献求助30
3分钟前
星辰大海应助微解感染采纳,获得10
3分钟前
3分钟前
3分钟前
华仔应助枯藤老柳树采纳,获得10
3分钟前
呆呆的猕猴桃完成签到 ,获得积分10
4分钟前
4分钟前
4分钟前
4分钟前
午后狂睡完成签到 ,获得积分10
4分钟前
5分钟前
高分求助中
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 2500
Future Approaches to Electrochemical Sensing of Neurotransmitters 1000
Electron microscopy study of magnesium hydride (MgH2) for Hydrogen Storage 1000
Finite Groups: An Introduction 800
壮语核心名词的语言地图及解释 700
ВЕРНЫЙ ДРУГ КИТАЙСКОГО НАРОДА СЕРГЕЙ ПОЛЕВОЙ 500
ВОЗОБНОВЛЕН ВЫПУСК ЖУРНАЛА "КИТАЙ" НА РУССКОМ ЯЗЫКЕ 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3906913
求助须知:如何正确求助?哪些是违规求助? 3452375
关于积分的说明 10870230
捐赠科研通 3178230
什么是DOI,文献DOI怎么找? 1755844
邀请新用户注册赠送积分活动 849133
科研通“疑难数据库(出版商)”最低求助积分说明 791370