Indole-3-acetamide from gut microbiota activated hepatic AhR and mediated the remission effect of Lactiplantibacillus plantarum P101 on alcoholic liver injury in mice

L. plantarum P101 alleviated alcoholic liver damage by regulating gut microbiota and its metabolites. The altered metabolite indole-3-acetamide activated the AhR signaling pathway and alleviated alcoholic injury in HepG2 cells.